I as well as explored whether or not Bmi modified the partnership ranging from thickness and risk of cancer of the breast passing ( Dining table 5)

Survival model results for the family members between mammographic thickness and you can chance of breast cancer demise, stratified by tumefaction attributes, AJCC degrees I–IV joint*

* Fully adjusted model includes covariates for AJCC stage (I, IIA, IIB, III, IV), registry (five sites), age at diagnosis (30–44, 45–49, 50–54, 55–59, 60–64, 65–69, 70–74, 75–79, ?80 years), year of diagnosis (1996–1998, 1999–2001, 2002–2003, 2004–2005), body mass index (18.5 – <25, 25 – <30, ?30kg/m 2 ), mode of detection (screen-detected, interval-detected, other screen, clinically detected, other), surgery/radiation (no breast surgery, breast conserving therapy without radiation, breast conserving therapy with radiation, other surgery), chemotherapy (yes/no), and annual median income (<$42 000, $42 000 – <$52 000, $52 000 – <$66 000, ?$66 000). Women with missing covariate information were excluded. AJCC = American Joint Committee on Cancer; BI-RADS = Breast Imaging Reporting and Data System; CI = confidence interval; ER = estrogen receptor; HR = hazard ratio; PR = progesterone receptor.

† P-well worth from Wald fact to test for an overall effectation of categorical BI-RADS density. Most of the mathematical tests had been a few-sided.

Letter = 96 female excluded out-of bring about-specific designs

007); specifically, elevated risk associated with having almost entirely fatty breasts was apparent for obese women (BMI ?30kg/m 2 , HR = 2.02, 95% CI = 1.37 to 2.97) but not overweight (BMI 25 – <30kg/m 2 , HR = 0.70, 95% CI = 0.40 to 1.23) or lean (BMI 18.5 – <25kg/m 2 , HR = 1.27, 95% CI = 0.74 to 2.17) women. To determine whether this association was being driven by a subgroup of women who were morbidly obese (BMI ?40kg/m 2 ), we conducted post hoc analyses after excluding 313 morbidly obese women, of whom 47 died of breast cancer. In BMI-stratified results, the elevated risk associated with having almost entirely fatty breasts remained apparent for obese women (BMI 30 – <40kg/m 2 , HR = 1.68, 95% CI = 1.07 to 2.63), and the interaction between breast density and BMI was still statistically significant (P = .01).

I located a mathematically high correspondence ranging from Bmi and you may BI-RADS density with regards to breast cancer death (P having communication =

* BI-RADS, Nipple Imaging Revealing and you can Study Program; Bmi, body mass index; CI, believe period; Hour, possibility ratio. All of the tumors: Body mass index ? occurrence interaction, P = .007.

† Fully adjusted model includes covariates for American Joint Committee on Cancer stage (I, IIA, IIB, III, IV), registry (five sites), age at diagnosis (30–44, 45–49, 50–54, 55–59, 60–64, 65–69, 70–74, 75–79, ?80 years), year of diagnosis (1996–1998, 1999–2001, 2002–2003, 2004–2005), mode of detection (screen-detected, interval-detected, other screen, clinically detected, other), surgery/radiation (no breast surgery, breast conserving therapy without radiation, breast conserving therapy with radiation, other surgery), chemotherapy (yes/no), and annual median income (<$42 000, $42 000 – <$52 000, $52 000 – <$66 000, ?$66 000). Women with missing covariate information were excluded.

‡ P worth out of Wald fact to test having a complete impact out-of categorical BI-RADS thickness. Every mathematical evaluation were a few-sided.

I discover a statistically extreme communication ranging from Bmi and you may BI-RADS occurrence when it comes to cancer of the breast death (P to own communications =

* BI-RADS, Nipple Imaging Revealing and Studies System; Bmi, body mass index; CI, trust period; Hr, danger ratio. All cancers: Body mass index ? thickness correspondence, P = .007.

† Fully adjusted model includes covariates for American Joint Committee on Cancer stage (I, IIA, IIB, III, IV), registry (five sites), age at diagnosis (30–44, 45–49, 50–54, 55–59, 60–64, 65–69, 70–74, 75–79 , ?80 years), year of diagnosis (1996–1998, 1999–2001, 2002–2003, 2004–2005), mode of detection (screen-detected, interval-detected, other screen, clinically detected, other), surgery/radiation (no breast surgery, breast conserving therapy without radiation, breast conserving therapy with radiation, other surgery), chemotherapy (yes/no), and annual median income (<$42 000, $42 000 – <$52 000, $52 000 – <$66 000, ?$66 000). Women with missing covariate information were excluded.

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